2-Cyanoethyl N,N,N′,N′-Tetraisopropylphosphorodiamidite
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چکیده
منابع مشابه
Properties of 5- and/or 2-modified 2'-O-cyanoethyl uridine residue: 2'-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component.
We systematically synthesized eight types of 5- and/or 2-modified uridine derivatives and evaluated their effect on duplex stability. The incorporation of 2'-O-cyanoethyl-2-thio-5-propynyluridine (p(5)s(2)UOCE) into RNA was significantly effective for stabilization of RNA/RNA (+8.5 °C) and DNA/RNA (+10.4 °C) duplexes. These striking effects were maintained in oligonucleotides with different seq...
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p27Kip1 is a cell cycle inhibitor that prevents cyclin dependent kinase (CDK)/cyclin complexes from phosphorylating their targets. p27Kip1 is a known tumor suppressor, as the germline loss of p27Kip1 results in sporadic pituitary formation in aged rodents, and its presence in human cancers is indicative of a poor prognosis. In addition to its role in cancer, loss of p27Kip1 results in regenerat...
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Trans- and cis-2-aryl-3-(2-cyanoethyl)aziridines, prepared via alkylation of the corresponding 2-aryl-3-(tosyloxymethyl)aziridines with the sodium salt of trimethylsilylacetonitrile, were transformed into variable mixtures of 4-[aryl(alkylamino)methyl]butyrolactones and 5-[aryl(hydroxy)methyl]pyrrolidin-2-ones via KOH-mediated hydrolysis of the cyano group, followed by ring expansion. In additi...
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A new series of 1-[(2, 5-dichloroanilinomalonyl)-3-(N-2’-cyanoethyl)-2-(Ncinnamoyl) 2, 5-dichloroanilino)]-5phenyl pyrazoline have been synthesized in 49 to 66% yield, by the reaction of N-cinnamoyl-N-2’-cyanoethyl-2,5dichloroaniline with 2-[(Ncinnamoyl) 2,5-dichloroanilido] acetohydrazide. Pyrazolines are yellow, cream and brown color solids, having high melting points. Identity of these produ...
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It is suggested that the observed excess of muons in studies of pp̄ collisions at √ s = 1.96 TeV arises from the decay of doubly-charged bosons. Such particles are predicted in the 3-3-1 model where the electroweak gauge group is extended to SU(3)× U(1). ∗[email protected]
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ژورنال
عنوان ژورنال: Synlett
سال: 2012
ISSN: 0936-5214,1437-2096
DOI: 10.1055/s-0032-1317955